Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat pancreatic beta-cells in response to INF gamma and/or IL-1 beta treatment for 6 or 24 hours

ABSTRACT: Type 1 diabetes is an autoimmune disease resulting from the selective destruction of insulin-producing beta-cells. Beta cell culture for 6-9 days in the presence of IL-1 beta and interferon (INF) gamma leads to apoptosis. Primary rat beta-cells were FACS purified and exposed for 6 or 24 h to control condition, IL-1 beta + INF gamma, or IL-1 beta alone (24 h only). The gene expression profile was analyzed by hybridization in duplicate to the Affymetrix RG U34A microarray.

ORGANISM(S): Rattus norvegicus

SUBMITTER: John Brestelli 

PROVIDER: E-CBIL-8 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of novel cytokine-induced genes in pancreatic beta-cells by high-density oligonucleotide arrays.

Cardozo A K AK   Kruhøffer M M   Leeman R R   Orntoft T T   Eizirik D L DL  

Diabetes 20010501 5

Type 1 diabetes is an autoimmune disease resulting from the selective destruction of insulin-producing beta-cells. Cytokines may contribute to pancreatic beta-cell death in type 1 diabetes. beta-cell exposure to interleukin (IL)-1beta induces functional impairment, whereas beta-cell culture for 6-9 days in the presence of IL-1beta and interferon (INF)-gamma leads to apoptosis. To clarify the mechanisms involved in these effects of cytokines, we studied the general pattern of cytokine-induced gen  ...[more]

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