CTTV020 epigenomes of cell lines PILOT
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000
ORGANISM(S): Homo sapiens
SUBMITTER:
PROVIDER: E-ERAD-369 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:These RNAseq experiments are carried out as part of the CTTV020 project to identify a gene expression signature of common immortalised cell lines / models. This signature / fingerprint will be used in combination with data from ChIPseq experiments from the same cell types to compare various human immortalised cell models against primary cells and tissues. The overall aims of the CTTV020 Cell Line Epigenome project are to establish a systematic approach for the determination of human biological & disease relevance through the generation of transciptomic and epigenomic data in cell types of interest \Integration of cell type mRNA expression and epigenome data with existing & newly generated reference data from human tissue and cell types to identify assay systems which will provide greater confidence in translating target biology and compound pharmacology to patients.\To provide a framework for the identification of optimal cell types for target identification/validation studies and drug discovery programs across multiple therapeutic areas. \Development of bioinformatics pipelines and CTTV components for analysis and provision of dataThis data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/
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