Cigarette Smoking Induces Overexpression of a Fat Depleting Gene AZGP1 in the Human Airway Epithelium
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Yael Strulovici-Barel
PROVIDER: E-GEOD-10135 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Cigarette smoking induces overexpression of a fat-depleting gene AZGP1 in the human.
Vanni Holly H Kazeros Angeliki A Wang Rui R Harvey Ben-Gary BG Ferris Barbara B De Bishnu P BP Carolan Brendan J BJ Hübner Ralf-Harto RH O'Connor Timothy P TP Crystal Ronald G RG
Chest 20090202 5
<h4>Background</h4>Smokers weigh less and have less body fat than nonsmokers. Increased body fat and weight gain are observed following smoking cessation. To assess a possible molecular mechanism underlying the inverse association between smoking and body weight, we hypothesized that smoking may induce the expression of a fat-depleting gene in the airway epithelium, the cell population that takes the brunt of the stress of cigarette smoke.<h4>Methods</h4>To assess whether smoking up-regulates ex ...[more]
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