Transcription profiling of human chronic lymphocytic leukemia samples from patients with stable or progressive disease

ABSTRACT: Chronic lymphocytic leukemia (CLL) is a heterogeneous malignancy, characterized by a variable clinical course. While clinical and laboratory parameters are increasingly being used to refine prognosis, they do not accurately predict response to commonly used therapy. We used gene expression profiling to generate and further refine prognostic and predictive markers. Genomic signatures that reflect progressive disease and responses to chemotherapy or chemo-immunotherapy were created using cancer cell lines and patient leukemia samples. We validated these signatures using independent clinical data from four separate cohorts representing a total of 301 CLL patients. A prognostic genomic signature created from patient leukemic cell gene expression data coupled with clinical parameters could

ORGANISM(S): Homo sapiens

SUBMITTER: Daphne Friedman 

PROVIDER: E-GEOD-10138 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress