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Transcription profiling of human acute quadriplegic myopathy patients

ABSTRACT: AQM shows acute muscle wasting and weakness. Key aspects of AQM include muscle atrophy and myofilament loss. Gene expression profiling, using muscle biopsies from AQM, neurogenic atrophy and normal controls, showed that both myogenic and neurogenic atrophy share induction of myofiber-specific ubiquitin/proteosome pathways while only the AQM shows a specific strong induction of transforming growth factor (TGF)-beta/MAPK pathways.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Eric Hoffman

PROVIDER: E-GEOD-1017 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Constitutive activation of MAPK cascade in acute quadriplegic myopathy.

Di Giovanni Simone S Molon Annamaria A Broccolini Aldobrando A Melcon Gisela G Mirabella Massimiliano M Hoffman Eric P EP Servidei Serenella S

Annals of neurology 20040201 2

Acute quadriplegic myopathy (AQM; also called "critical illness myopathy") shows acute muscle wasting and weakness and is experienced by some patients with severe systemic illness, often associated with administration of corticosteroids and/or neuroblocking agents. Key aspects of AQM include muscle atrophy and myofilament loss. Although these features are shared with neurogenic atrophy, myogenic atrophy in AQM appears mechanistically distinct from neurogenic atrophy. Using muscle biopsies from A ...[more]

PMID: 14755723

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