Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Alexandre Kuhn
PROVIDER: E-GEOD-10263 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kuhn Alexandre A Goldstein Darlene R DR Hodges Angela A Strand Andrew D AD Sengstag Thierry T Kooperberg Charles C Becanovic Kristina K Pouladi Mahmoud A MA Sathasivam Kirupa K Cha Jang-Ho J JH Hannan Anthony J AJ Hayden Michael R MR Leavitt Blair R BR Dunnett Stephen B SB Ferrante Robert J RJ Albin Roger R Shelbourne Peggy P Delorenzi Mauro M Augood Sarah J SJ Faull Richard L M RL Olson James M JM Bates Gillian P GP Jones Lesley L Luthi-Carter Ruth R
Human molecular genetics 20070521 15
To test the hypotheses that mutant huntingtin protein length and wild-type huntingtin dosage have important effects on disease-related transcriptional dysfunction, we compared the changes in mRNA in seven genetic mouse models of Huntington's disease (HD) and postmortem human HD caudate. Transgenic models expressing short N-terminal fragments of mutant huntingtin (R6/1 and R6/2 mice) exhibited the most rapid effects on gene expression, consistent with previous studies. Although changes in the bra ...[more]