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Changes in Prostate Gene Expression in a Cohort Undergoing an Intensive Nutrition and Lifestyle Intervention

ABSTRACT: The GEMINAL Study- Gene Expression Modulation by Intervention with Nutrition and Lifestyle We conducted a pilot study to examine changes in gene expression in men diagnosed with low risk prostate cancer who participated in an intensive nutrition and lifestyle intervention. We profiled gene expression in morphologically normal tissues from prostate biopsies of all 30 participants before and after the intervention. Keywords: Differential gene expression analysis Pre-intervention versus Post-Intervention

ORGANISM(S): Homo sapiens

SUBMITTER: Scot Federman

PROVIDER: E-GEOD-10306 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention.

Ornish Dean D Magbanua Mark Jesus M MJ Weidner Gerdi G Weinberg Vivian V Kemp Colleen C Green Christopher C Mattie Michael D MD Marlin Ruth R Simko Jeff J Shinohara Katsuto K Haqq Christopher M CM Carroll Peter R PR

Proceedings of the National Academy of Sciences of the United States of America 20080616 24

Epidemiological and prospective studies indicate that comprehensive lifestyle changes may modify the progression of prostate cancer. However, the molecular mechanisms by which improvements in diet and lifestyle might affect the prostate microenvironment are poorly understood. We conducted a pilot study to examine changes in prostate gene expression in a unique population of men with low-risk prostate cancer who declined immediate surgery, hormonal therapy, or radiation and participated in an int ...[more]

PMID: 18559852

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