Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Diane Thiboutot
PROVIDER: E-GEOD-10433 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nelson Amanda M AM Zhao Wei W Gilliland Kathryn L KL Zaenglein Andrea L AL Liu Wenlei W Thiboutot Diane M DM
The Journal of clinical investigation 20080401 4
13-cis retinoic acid (13-cis RA; also known as isotretinoin) is the most potent agent available for treatment of acne. It is known that the drug induces apoptosis in cells cultured from human sebaceous glands, but its mechanism of action has not been determined. In this study, skin biopsies were taken from 7 patients with acne prior to and at 1 week of treatment with 13-cis RA. TUNEL staining confirmed that 13-cis RA induced apoptosis in sebaceous glands. Transcriptional profiling of patient ski ...[more]