Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Takashi Tokino
PROVIDER: E-GEOD-10455 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Toyota Minoru M Suzuki Hiromu H Sasaki Yasushi Y Maruyama Reo R Imai Kohzoh K Shinomura Yasuhisa Y Tokino Takashi T
Cancer research 20080601 11
Altered expression of microRNA (miRNA) is strongly implicated in cancer, and recent studies have shown that, in cancer, expression of some miRNAs cells is silenced in association with CpG island hypermethylation. To identify epigenetically silenced miRNAs in colorectal cancer (CRC), we screened for miRNAs induced in CRC cells by 5-aza-2'-deoxycytidine (DAC) treatment or DNA methyltransferase knockout. We found that miRNA-34b (miR-34b) and miR-34c, two components of the p53 network, are epigeneti ...[more]