Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of mouse Bax null versus NGF-Bax double null animals


ABSTRACT: We report that developmental competition between sympathetic neurons for survival is critically dependent on a sensitization process initiated by target innervation and mediated by a series of feedback loops. Target-derived nerve growth factor (NGF) promoted expression of its receptor TrkA in neurons and prolonged TrkA-mediated signals. NGF also controlled expression of brain derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4), which, through the receptor p75, can kill neighboring neurons with low retrograde NGFâ??TrkA signaling whereas neurons with high NGFâ??TrkA signaling are protected. Perturbation of any of these feedback loops disrupts the dynamics of competition. We suggest that three target-initiated events are essential for rapid and robust competition between neurons: sensitization, paracrine apoptotic signaling, and protection from such effects. Experiment Overall Design: This experiment examine gene expression differences in superior cervical ganglia fro P0 bax null versus NGF-Bax double null animals. The Bax genotype was used in order to prevent the neuronal cell death normally observed in the NGF null animal.

ORGANISM(S): Mus musculus

SUBMITTER: David Ginty 

PROVIDER: E-GEOD-10498 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Similar Datasets

2008-04-09 | GSE10498 | GEO
| PRJNA625890 | ENA
2023-11-02 | GSE236673 | GEO
2023-11-02 | GSE236674 | GEO
2023-11-02 | GSE243814 | GEO
2023-11-02 | GSE236680 | GEO
2008-06-12 | E-GEOD-2864 | biostudies-arrayexpress
2023-11-27 | GSE245097 | GEO
| PRJNA107953 | ENA
2013-11-01 | GSE25611 | GEO