Dataset Information
Transcription profiling of Hep3B cells response hypoxia (1%O2) and cobalt chloride (100 uM) and deferoxamine (100 uM) and Nickel Chloride (100 uM)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: John LaPres
PROVIDER: E-GEOD-1056 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression profiling of hypoxia signaling in human hepatocellular carcinoma cells.
Physiological genomics 20050607 3
Cellular, local, and organismal responses to low O2 availability occur during processes such as anaerobic metabolism and wound healing and pathological conditions such as stroke and cancer. These responses include increases in glycolytic activity, vascularization, breathing, and red blood cell production. These responses are mediated in part by the hypoxia-inducible factors (HIFs), which receive information on O2 levels from a group of iron- and O2-dependent hydroxylases. Hypoxia mimics, such as ...[more]
