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Transcription profiling of human HL cell line associated gene expression changes compared with CD10+ GC B cells

ABSTRACT: Gene expression was compared between four B-cell derived HL cell lines (L428, L1236, L591, KMH2) and GC B cells from three different patients. Experiment Overall Design: Gene expression was compared between four B-cell derived HL cell lines (L428, L1236, L591, KMH2) and GC B cells from three different patients.

ORGANISM(S): Homo sapiens

SUBMITTER: Wenbin Wei 

PROVIDER: E-GEOD-10831 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The Epstein-Barr virus oncoprotein, latent membrane protein-1, reprograms germinal centre B cells towards a Hodgkin's Reed-Sternberg-like phenotype.

Vockerodt M M   Morgan S L SL   Kuo M M   Wei W W   Chukwuma M B MB   Arrand J R JR   Kube D D   Gordon J J   Young L S LS   Woodman C B CB   Murray P G PG  

The Journal of pathology 20080901 1

Although the latent membrane protein-1 (LMP1) of the Epstein-Barr virus (EBV) is believed to be important for the transformation of germinal centre (GC) B cells, the precise contribution of this viral oncogene to lymphoma development is poorly understood. In this study, we used a non-viral vector-based method to express LMP1 in primary human GC B cells. Gene expression profiling revealed that LMP1 induced in GC B cells transcriptional changes characteristic of Hodgkin's lymphoma cell lines. Stri  ...[more]

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