Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Loss of the retinoblastoma tumor suppressor is a common event in Basal-like and Luminal B breast carcinomas


ABSTRACT: Breast cancers can be classified using whole genome expression into distinct subtypes that show differences in patient prognosis. One of these groups, the basal-like carcinomas, are poorly differentiated, highly metastatic, and genomically unstable. These tumors also contain specific genetic alterations with one example being frequent p53 mutations. The loss of the tumor suppressor gene encoded by the retinoblastoma (RB1) locus is a well-characterized occurrence in many tumor types, however, its role in breast cancer is less clear with many reports demonstrating a Loss of Heterozygosity (LOH) that does not correlate with loss of RB1 protein expression. Here we report that LOH of the RB1 locus was observed at a high frequency in basal-like and luminal B tumors. These tumors also concurrently have low expression of RB1 mRNA as assessed by DNA microarray. As in previous reports, we also did not see a significant correlation between RB1 LOH and protein expression as measured by immunohistochemistry (IHC). p16INK4a, however, was highly expressed both by microarray and IHC, in basal-like tumors only presumably due to a previously reported feedback loop caused by RB1 loss. These results suggest that the functional loss of RB1 is a common event in the progression of basal-like and luminal B breast tumors, which may play a key role in dictating therapeutic responses Keywords: reference x sample Comparison of reference samples against treatment

ORGANISM(S): Homo sapiens

SUBMITTER: Jason Herschkowitz 

PROVIDER: E-GEOD-10884 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas.

Herschkowitz Jason I JI   He Xiaping X   Fan Cheng C   Perou Charles M CM  

Breast cancer research : BCR 20080909 5


<h4>Introduction</h4>Breast cancers can be classified using whole genome expression into distinct subtypes that show differences in prognosis. One of these groups, the basal-like subtype, is poorly differentiated, highly metastatic, genomically unstable, and contains specific genetic alterations such as the loss of tumour protein 53 (TP53). The loss of the retinoblastoma tumour suppressor encoded by the RB1 locus is a well-characterised occurrence in many tumour types; however, its role in breas  ...[more]

Similar Datasets

2011-06-20 | E-GEOD-26338 | biostudies-arrayexpress
2010-08-31 | E-GEOD-20624 | biostudies-arrayexpress
2010-10-25 | E-GEOD-15393 | biostudies-arrayexpress
2010-06-24 | E-GEOD-10886 | biostudies-arrayexpress
2009-04-01 | E-GEOD-10885 | biostudies-arrayexpress
2009-03-31 | E-GEOD-3521 | biostudies-arrayexpress
2013-04-22 | E-GEOD-36889 | biostudies-arrayexpress
2010-03-09 | E-GEOD-17916 | biostudies-arrayexpress
2014-07-29 | E-GEOD-41119 | biostudies-arrayexpress
2013-12-22 | E-GEOD-46604 | biostudies-arrayexpress