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Transcription profiling of human HIV seropositive patients, CD4+ T cell decline is predicted by differential expression

ABSTRACT: Patterns of expressed genes examined in cryopreserved peripheral blood mononuclear cells (PBMCs) of seropositive persons electing to stop antiretroviral therapy in the AIDS Clinical Trials Group Study A 5170, were scrutinized to identify markers capable of predicting the likelihood of CD4+ T cell depletion after cessation of ART. Two cohorts were matched for clinical characteristics in a study of the effects of therapy interruption (TI) in ART-treated patients with immunological preservation. Disease progression was determined by CD4+ T cell count decline 24 weeks after TI.Gene Set Enrichment Analysis (GSEA) identified a set of genes in the Ras signaling pathway, associated with the downregulation of apoptosis, as significantly upregulated in the good outcome group at cessation of ART. Experiment Overall Design: There are 96 samples in this study. 24 patients with good outcome results and 24 matched patients with poor outcome results. Each patient has two time points: week0 and week 24

ORGANISM(S): Homo sapiens

SUBMITTER: Maryanne Vahey

PROVIDER: E-GEOD-10924 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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CD4+ T Cell Decline is Predicted by Differential Expression of Genes in HIV seropositive patients

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