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Confirmation of the gene expression pattern in Mxi1-deficient mouse

ABSTRACT: For final aim to completes network map between gene that is concerned in cystogenesis, verifies meaning genes connected with cyst formation analyzing gene pattern in Mxi1 KO mouse that have phenotype of polycystic kidney disease. Monitoring meaning genes through microarray analysis, and confirm the function of these genes. Also, find pathway including meaning genes and new pathway related with PKD. Completes network map concerned in cystogenesis through integrates knowing pathway and predicting pathway. Develope diagnostic of cyst disease and cure target through such completed network map, and wish to clear new role of cyst formation connection gene through in vivo model and examine closely control system of cyst formation mechanism. Keywords: Cystogenesis Use 1 mouse at each experiment and control. Indirect labeling of 10g cRNA, using bacterial control mRNA.

ORGANISM(S): Mus musculus

SUBMITTER: Min Joo Lee

PROVIDER: E-GEOD-11053 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Inactivation of Mxi1 induces Il-8 secretion activation in polycystic kidney.

Yoo Kyung Hyun KH Sung Young Hoon YH Yang Moon Hee MH Jeon Jeong Ok JO Yook Yeon Joo YJ Woo Yu Mi YM Lee Han-Woong HW Park Jong Hoon JH

Biochemical and biophysical research communications 20070228 1

The Mxi1 proteins are biochemical and biological antagonists of c-myc oncoprotein. It has been reported that the overexpression pattern of c-myc might be similar to a molecular feature of early and late stages of human autosomal dominant polycystic kidney disease. We identified the cyst phenotype in Mxi1-deficient mice aged 6-12 months using H&E staining. Some chemokines containing a protein domain similar to human IL-8, which is associated with the inflammatory response, were subsequently selec ...[more]

PMID: 17350592

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Confirmation of the gene expression pattern in Mxi1-deficient mouse

Project description:For final aim to completes network map between gene that is concerned in cystogenesis, verifies meaning genes connected with cyst formation analyzing gene pattern in Mxi1 KO mouse that have phenotype of polycystic kidney disease. Monitoring meaning genes through microarray analysis, and confirm the function of these genes. Also, find pathway including meaning genes and new pathway related with PKD. Completes network map concerned in cystogenesis through integrates knowing pathway and predicting pathway. Develope diagnostic of cyst disease and cure target through such completed network map, and wish to clear new role of cyst formation connection gene through in vivo model and examine closely control system of cyst formation mechanism. Keywords: Cystogenesis

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