Unknown,Transcriptomics,Genomics,Proteomics

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Study of HepG2 cells transduced with HBX expressing recombinant Adenoviruses (AdHBx) and treated with UV

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE11064: AdHBx UV vs AdEasy UV vs HepG2 GSE11106: Chromatin Immunoprecipitation of UV treated AdHBx cells with anti-HBx antibodies Keywords: SuperSeries One-condition experiment, AdHBx (experimental) UV vs AdEasy (vector control) UV. HepG2 cells were infected with either recombinant HBx adenoviruses (AdHBx) or control adenoviruses (AdEasy). Seventy-two hours later, infected cells were exposed for 30 seconds to UVC (254 nm) irradiation with a germicidal lamp calibrated to deliver 8 or 16 J/m2. Cells were then harvested for either ChIP-chip profiling or expression microarray profiling.

ORGANISM(S): Homo sapiens

SUBMITTER: Wah Heng Lee 

PROVIDER: E-GEOD-11108 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Deregulated direct targets of the hepatitis B virus (HBV) protein, HBx, identified through chromatin immunoprecipitation and expression microarray profiling.

Sung Wing-Kin WK   Lu Yiwei Y   Lee Charlie W H CWH   Zhang Dongwei D   Ronaghi Mostafa M   Lee Caroline G L CGL  

The Journal of biological chemistry 20090513 33

The hepatitis B-X (HBx) protein is strongly associated with hepatocellular carcinoma. It is implicated not to directly cause cancer but to play a role in hepatocellular carcinoma as a co-factor. The oncogenic potential of HBx primarily lies in its interaction with transcriptional regulators resulting in aberrant gene expression and deregulated cellular pathways. Utilizing ultraviolet irradiation to simulate a tumor-initiating event, we integrated chip-based chromatin immunoprecipitation (ChIP-ch  ...[more]

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