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Transcription profiling of human lung tissue from emphysema and control patients

ABSTRACT: Gene expression profiling of lung tissue from undiseased (NML), 'usual' emphysema (EML), and Alpha-1 Antitrypsin Deficiency-related emphysema (ADL).

ORGANISM(S): Homo sapiens

DISEASE(S): alpha-1 antitrypsin deficiency-related emphysema

SUBMITTER: Christopher Coldren

PROVIDER: E-GEOD-1122 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Emphysema lung tissue gene expression profiling.

Golpon Heiko A HA Coldren Christopher D CD Zamora Martin R MR Cosgrove Gregory P GP Moore Mark D MD Tuder Rubin M RM Geraci Mark W MW Voelkel Norbert F NF

American journal of respiratory cell and molecular biology 20040729 6

Emphysema occurs in a subgroup of patients with chronic obstructive pulmonary disease and patients with the genetic defect of alpha(1)-antitrypsin deficiency who have a smoking history of many years' duration. Emphysema is generally the result of a chronic and progressive destruction of the alveolar structures, which is believed to be driven by chronic inflammation, infections, oxidative stress, and an imbalance of protease and antiprotease activity. Here, we use microarray technology to charact ...[more]

PMID: 15284076

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Emphysema Lung Tissue Gene Expression Profiling

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