Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Michael Dyer
PROVIDER: E-GEOD-1129 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Zhang Jiakun J Gray Jonathan J Wu Lizhao L Leone Gustavo G Rowan Sheldon S Cepko Constance L CL Zhu Xuemei X Craft Cheryl M CM Dyer Michael A MA
Nature genetics 20040229 4
The retinoblastoma protein (Rb) regulates proliferation, cell fate specification and differentiation in the developing central nervous system (CNS), but the role of Rb in the developing mouse retina has not been studied, because Rb-deficient embryos die before the retinas are fully formed. We combined several genetic approaches to explore the role of Rb in the mouse retina. During postnatal development, Rb is expressed in proliferating retinal progenitor cells and differentiating rod photorecept ...[more]