Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Molecular subtypes of DLBCL have distinct chromosomal aberrations

ABSTRACT: We performed array comparative genomic hybridization (aCGH) and gene expression profiling in 203 samples of diffuse large B cell lymphoma (DLBCL). By gene expression, at least three molecular subtypes of DLBCL termed as germinal center B cell-like (GCB) DLBCL, activated B cell-like (ABC) DLBCL, and primary mediastinal B cell lymphoma (PMBL) can be distinguished. Combining gene expression profiling and aCGH, revealed copy number abnormalities that had strikingly different frequencies in the three molecular DLBCL subtypes. These data provide genetic evidence that the DLBCL subtypes are distinct diseases that utilize different oncogenic pathways. Keywords: clinical history design The retrospective study included RNA and DNA extracted from 203 clinical samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Louis Staudt

PROVIDER: E-GEOD-11318 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways.

Lenz Georg G Wright George W GW Emre N C Tolga NC Kohlhammer Holger H Dave Sandeep S SS Davis R Eric RE Carty Shannon S Lam Lloyd T LT Shaffer A L AL Xiao Wenming W Powell John J Rosenwald Andreas A Ott German G Muller-Hermelink Hans Konrad HK Gascoyne Randy D RD Connors Joseph M JM Campo Elias E Jaffe Elaine S ES Delabie Jan J Smeland Erlend B EB Rimsza Lisa M LM Fisher Richard I RI Weisenburger Dennis D DD Chan Wing C WC Staudt Louis M LM

Proceedings of the National Academy of Sciences of the United States of America 20080902 36

Gene-expression profiling has been used to define 3 molecular subtypes of diffuse large B-cell lymphoma (DLBCL), termed germinal center B-cell-like (GCB) DLBCL, activated B-cell-like (ABC) DLBCL, and primary mediastinal B-cell lymphoma (PMBL). To investigate whether these DLBCL subtypes arise by distinct pathogenetic mechanisms, we analyzed 203 DLBCL biopsy samples by high-resolution, genome-wide copy number analysis coupled with gene-expression profiling. Of 272 recurrent chromosomal aberration ...[more]

PMID: 18765795

Dataset Information

Molecular subtypes of DLBCL have distinct chromosomal aberrations

Publications

Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways.

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