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Expression profiling of Liver tissue from C57BL/6J X C3H/HeJ)F2 and (C3H/HeJ X C57BL/6J )F2

ABSTRACT: The purpose of this experiment was to determine the expression traits in animals from F2 intercross of inbred strains C57BL/6J, C3H/HeJ. (N=309, 164 males and 145 females). Liver from 302 F2 female and male mice were generated by intercrossing F1 mice. Mice were fed chow diet containing 4% fat (Ralston-Purina Co., St. Louis, MO) until 8 weeks of age and then were placed on a high-fat "Western" diet containing 42% fat and 0.15% cholesterol (Teklad 88137, Harlan Teklad, Madison WI) for 12 weeks. At 20 weeks mice were sacrificed, after a 12-hour fast liver tissues were dissected and flash frozen in LN2 and stored at -80°C. Keywords=Genetics of Gene Expression Keywords Keywords=C57B1/J6 Keywords=C3H/HeJ

ORGANISM(S): Mus musculus

SUBMITTER: Leslie Ingram-drake 

PROVIDER: E-GEOD-11338 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Copy number variation influences gene expression and metabolic traits in mice.

Orozco Luz D LD   Cokus Shawn J SJ   Ghazalpour Anatole A   Ingram-Drake Leslie L   Wang Susanna S   van Nas Atila A   Che Nam N   Araujo Jesus A JA   Pellegrini Matteo M   Lusis Aldons J AJ  

Human molecular genetics 20090731 21

Copy number variants (CNVs) are genomic segments which are duplicated or deleted among different individuals. CNVs have been implicated in both Mendelian and complex traits, including immune and behavioral disorders, but the study of the mechanisms by which CNVs influence gene expression and clinical phenotypes in humans is complicated by the limited access to tissues and by population heterogeneity. We now report studies of the effect of 19 CNVs on gene expression and metabolic traits in a mous  ...[more]

PMID: 19648292

Publication: 1/2

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