Ontology highlight
ABSTRACT:
ORGANISM(S): Rattus norvegicus
SUBMITTER: Seung-Jae Lee
PROVIDER: E-GEOD-11574 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Lee He-Jin HJ Suk Ji-Eun JE Patrick Christina C Bae Eun-Jin EJ Cho Ji-Hoon JH Rho Sangchul S Hwang Daehee D Masliah Eliezer E Lee Seung-Jae SJ
The Journal of biological chemistry 20100113 12
Abnormal neuronal aggregation of alpha-synuclein is implicated in the development of many neurological disorders, including Parkinson disease and dementia with Lewy bodies. Glial cells also show extensive alpha-synuclein pathology and may contribute to disease progression. However, the mechanism that produces the glial alpha-synuclein pathology and the interaction between neurons and glia in the disease-inflicted microenvironment remain unknown. Here, we show that alpha-synuclein proteins releas ...[more]