Unknown,Transcriptomics,Genomics,Proteomics

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ChIP-Seq of human H1299 lung carcinoma cells - genomic location data for ectopic p73


ABSTRACT: The integral role of p53 in tumor suppression has promted many laboratories to perform extensive analyses of signaling pathways downstream of the p53 family of sequence-specific DNA binding transcription factors (p53 and its homologs p63 and p73). Despite the ability of p73 to regulate many p53 family target genes, little is known about the specific pathways that modulate p73 during development, tumorigenesis and tumor therapy. In this study we present a gene signature-based approach for connecting signaling pathways to transcription factors, as exemplified by p73. We generated a p73 gene signature by integrating whole-genome chromatin immunoprecipitation and expression profiling. Experiment Overall Design: H1299 lung carcinoma cells were transduced with TAp73beta or GFP expressing adenoviruses. Microarray analysis (on the GFP and TAp73beta samples) and ChIPSeq analysis (on the TAp73beta sample) were performed to identify candidate p73 target genes.

ORGANISM(S): Homo sapiens

SUBMITTER: Jennifer Pietenpol 

PROVIDER: E-GEOD-11672 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A gene signature-based approach identifies mTOR as a regulator of p73.

Rosenbluth Jennifer M JM   Mays Deborah J DJ   Pino Maria F MF   Tang Luo Jia LJ   Pietenpol Jennifer A JA  

Molecular and cellular biology 20080804 19


Although genomic technologies have advanced the characterization of gene regulatory networks downstream of transcription factors, the identification of pathways upstream of these transcription factors has been more challenging. In this study we present a gene signature-based approach for connecting signaling pathways to transcription factors, as exemplified by p73. We generated a p73 gene signature by integrating whole-genome chromatin immunoprecipitation and expression profiling. The p73 signat  ...[more]

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