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Gene expression profiles of reactive stroma in prostate cancer

ABSTRACT: This is an analysis of stroma from 17 Grade 3 reactive stroma prostate cancer tissues and matched normal peripheral zone tissues. Keywords: two group comparison Laser capture microdissection and expression array analysis of stroma from 17 Grade 3 reactive stroma prostate cancer tissues and matched normal peripheral zone tissues.

ORGANISM(S): Homo sapiens

SUBMITTER: Chad Creighton

PROVIDER: E-GEOD-11682 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Global gene expression analysis of reactive stroma in prostate cancer.

Dakhova Olga O Ozen Mustafa M Creighton Chad J CJ Li Rile R Ayala Gustavo G Rowley David D Ittmann Michael M

Clinical cancer research : an official journal of the American Association for Cancer Research 20090609 12

<h4>Purpose</h4>Marked reactive stroma formation, designated as grade 3 reactive stroma, is associated with poor outcome in clinically localized prostate cancer. To understand the biological processes and signaling mechanisms underlying the formation of such reactive stroma, we carried out microarray gene expression analysis of laser-captured reactive stroma and matched normal stroma.<h4>Experimental design</h4>Seventeen cases of reactive stroma grade 3 cancer were used to laser-capture tumor an ...[more]

PMID: 19509179

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