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TGF-beta responsive gene in primary osteoblast.

ABSTRACT: Gene expression profiling of a total of 3,774 genes in primary osteoblastic cells treated with TGF-beta1 Keywords: cytokine response Primary osteoblasts cultured under serum-starved condition were treated or untreated with TGF-beta1 for 24 hr.

ORGANISM(S): Mus musculus

SUBMITTER: Tomoki Chiba

PROVIDER: E-GEOD-11702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation.

Kim Minsoo M Nakamoto Takashi T Nishimori Shigeki S Tanaka Keiji K Chiba Tomoki T

EMBO reports 20080725 9

Transforming growth factor-beta1 (TGF-beta1) has many physiological functions and inhibits the differentiation of osteoblasts. Previously, we reported that TGF-beta1 stimulation induces the degradation of p57(KIP2) in osteoblasts. p57(KIP2) proteolysis depends on the ubiquitin-proteasome pathway and SMAD-mediated transcription; however, the molecular mechanism underlying p57(KIP2) degradation has been largely unknown. Here, we show that FBL12, a new F-box protein expressed in the limb bud of dev ...[more]

PMID: 18660753

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