Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: James Ruby
PROVIDER: E-GEOD-11734 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Batista Pedro J PJ Ruby J Graham JG Claycomb Julie M JM Chiang Rosaria R Fahlgren Noah N Kasschau Kristin D KD Chaves Daniel A DA Gu Weifeng W Vasale Jessica J JJ Duan Shenghua S Conte Darryl D Luo Shujun S Schroth Gary P GP Carrington James C JC Bartel David P DP Mello Craig C CC
Molecular cell 20080619 1
In metazoans, Piwi-related Argonaute proteins have been linked to germline maintenance, and to a class of germline-enriched small RNAs termed piRNAs. Here we show that an abundant class of 21 nucleotide small RNAs (21U-RNAs) are expressed in the C. elegans germline, interact with the C. elegans Piwi family member PRG-1, and depend on PRG-1 activity for their accumulation. The PRG-1 protein is expressed throughout development and localizes to nuage-like structures called P granules. Although 21U- ...[more]