Unknown,Transcriptomics,Genomics,Proteomics

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Microarray-based comparative genomic profiling of reference strains of Actinobacillus pleuropneumoniae


ABSTRACT: Microarray-based comparative genomic hybridizations were used to estimate whole genomic diversity of representative Actinobacillus pleuropneumoniae strains. Our goal was to identify conserved genes, especially those predicted to encode outer membrane proteins and lipoproteins because of their potential for the development of more effective vaccines. Keywords: Comparative Genomic Hybridisation Microarray data for 15 known serotypes of Actinobacillus pleuropneumoniae (at least 2 replicates per serotype).

ORGANISM(S): Actinobacillus pleuropneumoniae

SUBMITTER: John Nash 

PROVIDER: E-GEOD-11921 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Microarray-based comparative genomic profiling of reference strains and selected Canadian field isolates of Actinobacillus pleuropneumoniae.

Gouré Julien J   Findlay Wendy A WA   Deslandes Vincent V   Bouevitch Anne A   Foote Simon J SJ   MacInnes Janet I JI   Coulton James W JW   Nash John H E JH   Jacques Mario M  

BMC genomics 20090224


<h4>Background</h4>Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, is a highly contagious respiratory pathogen that causes severe losses to the swine industry worldwide. Current commercially-available vaccines are of limited value because they do not induce cross-serovar immunity and do not prevent development of the carrier state. Microarray-based comparative genomic hybridizations (M-CGH) were used to estimate whole genomic diversity of representative Actinobac  ...[more]

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