Aging study
Ontology highlight
ABSTRACT:
ORGANISM(S): Caenorhabditis elegans
SUBMITTER: Stuart Kim
PROVIDER: E-GEOD-12094 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
An elt-3/elt-5/elt-6 GATA transcription circuit guides aging in C. elegans.
Budovskaya Yelena V YV Wu Kendall K Southworth Lucinda K LK Jiang Min M Tedesco Patricia P Johnson Thomas E TE Kim Stuart K SK
Cell 20080701 2
To define the C. elegans aging process at the molecular level, we used DNA microarray experiments to identify a set of 1294 age-regulated genes and found that the GATA transcription factors ELT-3, ELT-5, and ELT-6 are responsible for age regulation of a large fraction of these genes. Expression of elt-5 and elt-6 increases during normal aging, and both of these GATA factors repress expression of elt-3, which shows a corresponding decrease in expression in old worms. elt-3 regulates a large numbe ...[more]
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