Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Marcel Smid
PROVIDER: E-GEOD-12276 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Bos Paula D PD Zhang Xiang H-F XH Nadal Cristina C Shu Weiping W Gomis Roger R RR Nguyen Don X DX Minn Andy J AJ van de Vijver Marc J MJ Gerald William L WL Foekens John A JA Massagué Joan J
Nature 20090506 7249
The molecular basis for breast cancer metastasis to the brain is largely unknown. Brain relapse typically occurs years after the removal of a breast tumour, suggesting that disseminated cancer cells must acquire specialized functions to take over this organ. Here we show that breast cancer metastasis to the brain involves mediators of extravasation through non-fenestrated capillaries, complemented by specific enhancers of blood-brain barrier crossing and brain colonization. We isolated cells tha ...[more]