Differential gene expression in GBS6 cells after EWS-POU5F1 knockdown
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Takashi Fujino
PROVIDER: E-GEOD-12320 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Function of EWS-POU5F1 in sarcomagenesis and tumor cell maintenance.
Fujino Takashi T Nomura Kimie K Ishikawa Yuichi Y Makino Hatsune H Umezawa Akihiro A Aburatani Hiroyuki H Nagasaki Koichi K Nakamura Takuro T
The American journal of pathology 20100304 4
POU5F1 is a transcription factor essential for the self-renewal activity and pluripotency of embryonic stem cells and germ cells. We have previously reported that POU5F1 is fused to EWSR1 in a case of undifferentiated sarcoma with chromosomal translocation t(6;22)(p21;q12). In addition, the EWS-POU5F1 chimeras have been recently identified in human neoplasms of the skin and salivary glands. To clarify the roles of the EWS-POU5F1 chimera in tumorigenesis and tumor cell maintenance, we used small- ...[more]
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