Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Lothar Strobl
PROVIDER: E-GEOD-12355 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Blood 20090401 22
The canonical mode of transcriptional activation by both the Epstein-Barr viral protein, Epstein-Barr virus-encoded nuclear antigen 2 (EBNA2), and an activated Notch receptor (Notch-IC) requires their recruitment to RBPJ, suggesting that EBNA2 uses the Notch pathway to achieve B-cell immortalization. To gain further insight into the biologic equivalence between Notch-IC and EBNA2, we performed a genome-wide expression analysis, revealing that Notch-IC and EBNA2 exhibit profound differences in th ...[more]