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Secreted transcription factor controls Mycobacterium tuberculosis virulence

ABSTRACT: This SuperSeries is composed of the following subset Series: GSE11696: Gene expression profile of M.tuberculosis espR (Rv3849) mutant GSE12379: Gene expression profile of M.tuberculosis espR (Rv3849) mutant complemented with an N-terminal Flag espR gene GSE12380: Gene expression profile of M.tuberculosis espR (Rv3849) mutants containing N- or C-terminal mutations in the espR gene GSE12381: Comparative analysis of the gene expression profiles of M.tuberculosis espR (Rv3849) transposon and knockout mutants Refer to individual Series

ORGANISM(S): Mycobacterium tuberculosis

SUBMITTER: Paolo Manzanillo

PROVIDER: E-GEOD-12382 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Secreted transcription factor controls Mycobacterium tuberculosis virulence.

Raghavan Sridharan S Manzanillo Paolo P Chan Kaman K Dovey Cole C Cox Jeffery S JS

Nature 20080801 7205

Bacterial pathogens trigger specialized virulence factor secretion systems on encountering host cells. The ESX-1 protein secretion system of Mycobacterium tuberculosis-the causative agent of the human disease tuberculosis-delivers bacterial proteins into host cells during infection and is critical for virulence, but how it is regulated is unknown. Here we show that EspR (also known as Rv3849) is a key regulator of ESX-1 that is required for secretion and virulence in mice. EspR activates transcr ...[more]

PMID: 18685700

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Gene expression profile of M.tuberculosis espR (Rv3849) mutant complemented with an N-terminal Flag espR gene

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Gene expression profile of M.tuberculosis espR (Rv3849) mutants containing N- or C-terminal mutations in the espR gene

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