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Changes in cardiac transcription profiles following on-pump coronary artery bypass grafting

ABSTRACT: To investigate changes in cardiac transcription profiles caused by on-pump cardiac surgery, we collected myocardial samples, prior and after grafting, from patients undergoing on-pump coronary artery bypass grafting with cardiopulmonary bypass and cardiac arrest. The transcriptional profile of the mRNA in these samples was measured with gene array technology. Changes in transcriptional profiles can be correlated with the stress response of heart to surgery, cardiopulmonary bypass and cardiac arrest. Keywords: human, cardiac, CABG coronary surgery, gene expression, cardiopulmonary bypass. Myocardial samples were collected, prior and after grafting, from patients undergoing on-pump coronary artery bypass grafting with cardiopulmonary bypass and cardiac arrest.

ORGANISM(S): Homo sapiens

SUBMITTER: Gianni Angelini 

PROVIDER: E-GEOD-12486 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Off-pump coronary artery bypass surgery is associated with fewer gene expression changes in the human myocardium in comparison with on-pump surgery.

Ghorbel Mohamed T MT   Cherif Myriam M   Mokhtari Amir A   Bruno Vito Domenico VD   Caputo Massimo M   Angelini Gianni D GD  

Physiological genomics 20100323 1

Off-pump coronary artery bypass surgery reduces the myocardial injury associated with on pump surgery with cardiopulmonary bypass (CPB) and ischemic-cardioplegic arrest (CA). We sought to find a mechanistic explanation for this by comparing the transcriptomic changes in the myocardium of patients undergoing on- and off-pump surgery. Transcriptomic analyses were performed on left ventricular biopsies obtained from patients prior to (pre-op) and after completion of all coronary anastomoses (post-o  ...[more]

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