Ontology highlight
ABSTRACT:
ORGANISM(S): Danio rerio
SUBMITTER: Sukhbir Kaur
PROVIDER: E-GEOD-12516 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Chun Chang Z CZ Kaur Sukhbir S Samant Ganesh V GV Wang Ling L Pramanik Kallal K Garnaas Maija K MK Li Keguo K Field Lyndsay L Mukhopadhyay Debabrata D Ramchandran Ramani R
Blood 20080822 5
In vertebrates, molecular mechanisms dictate angioblasts' migration and subsequent differentiation into arteries and veins. In this study, we used a microarray screen to identify a novel member of the sucrose nonfermenting related kinase (snrk-1) family of serine/threonine kinases expressed specifically in the embryonic zebrafish vasculature and investigated its function in vivo. Using gain- and loss-of-function studies in vivo, we show that Snrk-1 plays an essential role in the migration, maint ...[more]