Unknown,Transcriptomics,Genomics,Proteomics

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Differentially expressed genes in zebrafish vascular development


ABSTRACT: The goal of this experiment was to identify using tissue specific transgenic zebrafish (Fli:EGFP), genes of interest important for embryonic vascular development. Keywords: time course, GFP cell isolation, zebrafish The experiment contained 6 samples. A18, A24 = total RNA isolated from 18 and 24 hpf zebrafish embryo; B2, C and D2=RNA isolated from GFP positive cells sorted at 18, 24 and 28 hpf respectively from Tg(Fli1:EGFP) embryos; E2 = RNA isolated from GFP positive cells sorted at 18 hpf from Tg(Flk:GRCFP) embryos.

ORGANISM(S): Danio rerio

SUBMITTER: Sukhbir Kaur 

PROVIDER: E-GEOD-12516 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates.

Chun Chang Z CZ   Kaur Sukhbir S   Samant Ganesh V GV   Wang Ling L   Pramanik Kallal K   Garnaas Maija K MK   Li Keguo K   Field Lyndsay L   Mukhopadhyay Debabrata D   Ramchandran Ramani R  

Blood 20080822 5


In vertebrates, molecular mechanisms dictate angioblasts' migration and subsequent differentiation into arteries and veins. In this study, we used a microarray screen to identify a novel member of the sucrose nonfermenting related kinase (snrk-1) family of serine/threonine kinases expressed specifically in the embryonic zebrafish vasculature and investigated its function in vivo. Using gain- and loss-of-function studies in vivo, we show that Snrk-1 plays an essential role in the migration, maint  ...[more]

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