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Gene expression profile of normal and calcified stenotic human aortic valves

ABSTRACT: We explored gene expression profile of human aortic valves in patients with or without aortic stenosis. The dataset that we generated constitutes a large-scale quantitative measurements of gene expression in normal and stenotic human valves. The goal was to compare gene expression levels between the two groups and identified a list of genes that are up- or down-regulated in aortic stenosis. Keywords: disease state analysis Gene expression was performed on ten normal and ten aortic stenosis valves

ORGANISM(S): Homo sapiens

SUBMITTER: Yohan Bossé

PROVIDER: E-GEOD-12644 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Increased biglycan in aortic valve stenosis leads to the overexpression of phospholipid transfer protein via Toll-like receptor 2.

Derbali Habib H Bossé Yohan Y Côté Nancy N Pibarot Philippe P Audet Audrey A Pépin Andree A Arsenault Benoit B Couture Christian C Després Jean-Pierre JP Mathieu Patrick P

The American journal of pathology 20100409 6

Aortic stenosis (AS) is the most common valvular heart disease, and it is suspected that atherosclerotic mechanisms are involved in the development of this disorder. Therefore, the retention of lipids within the aortic valve may play a role in the pathobiology of AS. In this study, a gene expression microarray experiment was conducted on human aortic valves with and without AS. The expression levels of transcripts encoding proteoglycans and enzymes involved in lipid retention were compared betwe ...[more]

PMID: 20382708

Publication: 1/2

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