Whole heart response to stable HIF-1alpha overexpression

ABSTRACT: An oxygen stable form of HIF-1alpha was overexpressed in the hearts of mice, under tet-off control. Bi-allelic transgenic mice were created by crossing alpha-MHC promoter/tet transactivating protein expressing mice with tet responsive element promter/stable HIF-1alpha protein expressing mice. Mice were either, maintained on Doxycycline (inhibiting the expression of the HIF-1alpha transgene) or removed from doxycycline (inducing expression) for one or three days.

ORGANISM(S): Mus musculus

SUBMITTER: Chad Walton 

PROVIDER: E-GEOD-12673 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress