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Trap-80-dependence of TNF-alpha-induced genes

ABSTRACT: In fibroblasts, p65-dependent genes can be sub-divided, depending on whether they are Trap-80-dependent or -independent. To examine the generality of this grouping, we performed a microarray analysis of wild-type and Trap-80 knock-down fibroblasts, before and after stimulation of NF-kappaB activity using TNF-alpha. RNA was extracted from three independent cultures of wild-type and Trap-80 knock-down fibroblasts, before and after stimulation for 1 hour with 5ng/ml TNF-alpha. The unstimulated and stimulated wild-type samples, and the stimulated Trap-80 knock-down samples, were used for microarray analysis.

ORGANISM(S): Mus musculus

SUBMITTER: Gioacchino Natoli 

PROVIDER: E-GEOD-12697 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Two modes of transcriptional activation at native promoters by NF-kappaB p65.

van Essen Dominic D   Engist Bettina B   Natoli Gioacchino G   Saccani Simona S  

PLoS biology 20090301 3

The NF-kappaB family of transcription factors is crucial for the expression of multiple genes involved in cell survival, proliferation, differentiation, and inflammation. The molecular basis by which NF-kappaB activates endogenous promoters is largely unknown, but it seems likely that it should include the means to tailor transcriptional output to match the wide functional range of its target genes. To dissect NF-kappaB-driven transcription at native promoters, we disrupted the interaction betwe  ...[more]

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