Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression in human myeloid cells


ABSTRACT: Human myelopoiesis is an exciting biological model for cellular differentiation since it represents a plastic process where pluripotent stem cells gradually limit their differentiation potential, generating different precursor cells which finally evolve into distinct terminally differentiated cells. This study aimed at investigating the genomic expression during myeloid differentiation through a computational approach that integrates gene expression profiles with functional information and genome organization. The genomic distribution of myelopoiesis genes was investigated integrating transcriptional and functional characteristics of genes. The analysis of genomic expression during human myelopoiesis using an integrative computational approach allowed discovering important relationships between genomic position, biological function and expression patterns and highlighting chromatin domains, including genes with coordinated expression and lineage-specific functions. Keywords: cell differentiation Gene expression data from 20 experiments for 8 different cell types of the human myelopoietic lineage were used to generate an integrated myelopoiesis dataset.

ORGANISM(S): Homo sapiens

SUBMITTER: Francesco Ferrari 

PROVIDER: E-GEOD-12803 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Motif discovery in promoters of genes co-localized and co-expressed during myeloid cells differentiation.

Coppe Alessandro A   Ferrari Francesco F   Bisognin Andrea A   Danieli Gian Antonio GA   Ferrari Sergio S   Bicciato Silvio S   Bortoluzzi Stefania S  

Nucleic acids research 20081205 2


Genes co-expressed may be under similar promoter-based and/or position-based regulation. Although data on expression, position and function of human genes are available, their true integration still represents a challenge for computational biology, hampering the identification of regulatory mechanisms. We carried out an integrative analysis of genomic position, functional annotation and promoters of genes expressed in myeloid cells. Promoter analysis was conducted by a novel multi-step method fo  ...[more]

Publication: 1/2

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