Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Alan Berger
PROVIDER: E-GEOD-12839 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Watford Wendy T WT Hissong Bruce D BD Durant Lydia R LR Yamane Hidehiro H Muul Linda M LM Kanno Yuka Y Tato Cristina M CM Ramos Haydeé L HL Berger Alan E AE Mielke Lisa L Pesu Marko M Solomon Benjamin B Frucht David M DM Paul William E WE Sher Alan A Jankovic Dragana D Tsichlis Philip N PN O'Shea John J JJ
The Journal of experimental medicine 20081110 12
Tpl2 (Tumor progression locus 2), also known as Cot/MAP3K8, is a hematopoietically expressed serine-threonine kinase. Tpl2 is known to have critical functions in innate immunity in regulating tumor necrosis factor-alpha, Toll-like receptor, and G protein-coupled receptor signaling; however, our understanding of its physiological role in T cells is limited. We investigated the potential roles of Tpl2 in T cells and found that it was induced by interleukin-12 in human and mouse T cells in a Stat4- ...[more]