Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Wilfried Gouraud
PROVIDER: E-GEOD-12896 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Avet-Loiseau Hervé H Li Cheng C Magrangeas Florence F Gouraud Wilfried W Charbonnel Catherine C Harousseau Jean-Luc JL Attal Michel M Marit Gerald G Mathiot Claire C Facon Thierry T Moreau Philippe P Anderson Kenneth C KC Campion Loïc L Munshi Nikhil C NC Minvielle Stéphane S
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090817 27
<h4>Purpose</h4>Chromosomal aberrations are a hallmark of multiple myeloma but their global prognostic impact is largely unknown.<h4>Patients and methods</h4>We performed a genome-wide analysis of malignant plasma cells from 192 newly diagnosed patients with myeloma using high-density, single-nucleotide polymorphism (SNP) arrays to identify genetic lesions associated with prognosis.<h4>Results</h4>Our analyses revealed deletions and amplifications in 98% of patients. Amplifications in 1q and del ...[more]