Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptomic analysis for response of EHEC to short chain fatty acids


ABSTRACT: Enterohaemorrhagic Escherichia coli (EHEC) is an emerging pathogen that causes diarrhea and heamolytic uremic syndrome. Expression of genes associated to pathogenicity is strictly regulated by environmental factors. Since short chian fatty acids (SCFAs) are present in intestinal tract which is a target of EHEC infection, we investigated the response of EHEC genes to SCFAs, such as acetate, propionate and butyrate. Keywords: Culture condition 3 sets of comparison between transcription profiles in EHEC growing in the presence of acetate, propionate or butyrate against EHEC growing in the presence of NaCl. Labelling of cDNA and hybridization were performed twice with independently prepared RNAs.

ORGANISM(S): Escherichia coli

SUBMITTER: Toru Tobe 

PROVIDER: E-GEOD-12903 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Regulation of virulence by butyrate sensing in enterohaemorrhagic Escherichia coli.

Nakanishi Noriko N   Tashiro Kosuke K   Kuhara Satoru S   Hayashi Tetsuya T   Sugimoto Nakaba N   Tobe Toru T  

Microbiology (Reading, England) 20090201 Pt 2


Enterohaemorrhagic Escherichia coli (EHEC) colonizes and proliferates at the mucosal surface, inducing severe diarrhoea. Short-chain fatty acids (SCFAs) are abundant in the intestine owing to the metabolic activity of microflora, and are important for colonic health. We found that, although a high concentration of SCFAs inhibited the growth of EHEC, at low concentrations, the SCFAs markedly enhanced the expression of the virulence genes required for cell adherence and the induction of attaching  ...[more]

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