Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Chris Ottolenghi
PROVIDER: E-GEOD-12905 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Garcia-Ortiz José Elias JE Pelosi Emanuele E Omari Shakib S Nedorezov Timur T Piao Yulan Y Karmazin Jesse J Uda Manuela M Cao Antonio A Cole Steve W SW Forabosco Antonino A Schlessinger David D Ottolenghi Chris C
BMC developmental biology 20090618
<h4>Background</h4>Partial loss of function of the transcription factor FOXL2 leads to premature ovarian failure in women. In animal models, Foxl2 is required for maintenance, and possibly induction, of female sex determination independently of other critical genes, e.g., Rspo1. Here we report expression profiling of mouse ovaries that lack Foxl2 alone or in combination with Wnt4 or Kit/c-Kit.<h4>Results</h4>Following Foxl2 loss, early testis genes (including Inhbb, Dhh, and Sox9) and several no ...[more]