Transcription profiling of human hippocampus samples from patients with Alzheimers disease of varying severity

ABSTRACT: For these data, we analyzed hippocampal gene expression of nine control and 22 AD subjects of varying severity on 31 separate microarrays. We then tested the correlation of each gene's expression with MiniMental Status Examination (MMSE) and neurofibrillary tangle (NFT) scores across all 31 subjects regardless of diagnosis. These tests revealed a major transcriptional response comprising thousands of genes significantly correlated with AD markers. Several hundred of these genes were also correlated with AD markers across only control and incipient AD subjects (MMSE > 20).

ORGANISM(S): Homo sapiens

SUBMITTER: Eric Blalock 

PROVIDER: E-GEOD-1297 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress