Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Effect of P. gingivalis on human primary gingival epithelial cells

ABSTRACT: EXPERIMENT: Microarray expression profiles derived from the human primary gingival epithelial cells 24.0h after exposure to heat inactivated P. gingivalis ANIMAL MODEL: NON EXPOSURE: Human primary gingival epithelial cells (at 3rd passage) were exposed to heat inactivated P. gingivalis (MOI:100) at 90% confluence. Two types of gingival epithelial cells were used. One with Normal cytokine inducer type (at least 2 fold IL-6/TNF-alpha/IL-1ß when challenged with TLR2/4 agonists) and the other with diminished cytokine inducer type (no change in IL-6/TNF-alpha/IL-1ß when challenged with TLR2/4 agonists). INTERVAL: NON. PLATFORM: microRNA expression profile in gingival epithelial cells - miRCURY LNA™ microRNA Arrays (Exiqon). The RNA samples were subjected to microarray on 8/9/2007 Keywords = Human primary gingival epithelial cells Keywords = P. gingivalis Keywords = Periodontitis Keywords: Ordered The effect of heat inactivated P. gingivalison human primary gingival epithelial cells were assayed.

ORGANISM(S): Homo sapiens

SUBMITTER: Denis Kinane 

PROVIDER: E-GEOD-13042 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

Json Xml
altmetric image

Publications

Modulation of TLR2 protein expression by miR-105 in human oral keratinocytes.

Benakanakere Manjunatha R MR   Li Qiyan Q   Eskan Mehmet A MA   Singh Amar V AV   Zhao Jiawei J   Galicia Johnah C JC   Stathopoulou Panagiota P   Knudsen Thomas B TB   Kinane Denis F DF  

The Journal of biological chemistry 20090609 34

Mammalian biological processes such as inflammation, involve regulation of hundreds of genes controlling onset and termination. MicroRNAs (miRNAs) can translationally repress target mRNAs and regulate innate immune responses. Our model system comprised primary human keratinocytes, which exhibited robust differences in inflammatory cytokine production (interleukin-6 and tumor necrosis factor-alpha) following specific Toll-like receptor 2 and 4 (TLR-2/TLR-4) agonist challenge. We challenged these  ...[more]

Similar Datasets

Genomics Effect of P. gingivalis on human primary gingival epithelial cells
2008-11-07 | GSE13042 | GEO
Transcriptomics Explore the gene expression files of HGECs after P. gingivalis persisters treatment via RNA sequencing
2022-05-31 | GSE184777 | GEO
Other Differential protein expression by Porphyromonas gingivalis in response to secreted epithelial cell components
2005-09-17 | GSE3322 | GEO
Transcriptomics Gingival Epithelial Cell Responses to a Complex Microbiome Comprising Commensal and Opportunistic Oral Microbial Species
2009-07-14 | GSE12121 | GEO
Transcriptomics Gingival Epithelial Cell Transcriptional Responses to Pathogenic Oral Microbial Species.
2008-03-01 | GSE9723 | GEO
Transcriptomics Transcription profiling of human gingival epithelial cells responses to pathogenic oral microbial species.
2009-04-24 | E-GEOD-9723 | biostudies-arrayexpress
Proteomics membrane substrates of gingipains
2020-04-28 | PXD015679 | Pride
Transcriptomics Transcription profiling of human oral keratinocytes was utilized to define the biological role of P. gingivalis in gingival epithelial cell cytoskeletal remodeling and cytokine production
2008-06-18 | E-GEOD-10526 | biostudies-arrayexpress
Transcriptomics Transcription profiling by array of human gingival epithelial cell responses to a complex microbiome
2009-07-18 | E-GEOD-12121 | biostudies-arrayexpress
Proteomics Identification of Siglec ligands in human B cell
2017-09-29 | PXD006359 | Pride