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Microarray analysis of Huh7 cells treated with IFNa2, OSM or IFNa2 combined with OSM

ABSTRACT: OSM increases the antiviral effect of IFNα in Huh7 cells infected with hepatitis A virus (HAV) or HCV replicon and synergizes with IFNα in the induction of antiviral genes 16 samples. Four replicates for each experimental condition. 72 hours of treatment in DMEM supplemented with 2% FBS.

ORGANISM(S): Homo sapiens

SUBMITTER: Iranzu Gonzalez

PROVIDER: E-GEOD-13046 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells.

Larrea Esther E Aldabe Rafael R Gonzalez Iranzu I Segura Victor V Sarobe Pablo P Echeverria Itziar I Prieto Jesus J

Journal of virology 20090121 7

Oncostatin M (OSM) is released together with type I interferon (IFN) by activated dendritic cells, suggesting a concerted action of these cytokines in the biological response against infection. We found that OSM increases the antiviral effect of IFN-alpha in Huh7 hepatoma cells infected with hepatitis A or hepatitis C virus and synergizes with IFN-alpha in the induction of antiviral genes. The combination of OSM and IFN-alpha led to upregulation of both STAT1 and STAT3 together with intense and ...[more]

PMID: 19158240

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IFNα-mediated gene expression patterns

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2010-07-23 | E-GEOD-17302 | biostudies-arrayexpress

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Project description:OSM increases the antiviral effect of IFNα in Huh7 cells infected with hepatitis A virus (HAV) or HCV replicon and synergizes with IFNα in the induction of antiviral genes

2009-01-21 | GSE13046 | GEO

Direct effects of IFNα on human CD8 T cells_without any other concomitant signals

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2010-07-23 | E-GEOD-17299 | biostudies-arrayexpress

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2010-07-23 | E-GEOD-17301 | biostudies-arrayexpress

Crosstalk between very different family members: How STAT3 activating IL6-type cytokines inhibit the IFNg-like responses of IL27 in hepatocellular carcinoma cells

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2017-07-05 | E-MTAB-4570 | biostudies-arrayexpress

Response of several cell lines originated from liver, skin and colon to stimulation by IFNg, hyper-IL6, IL27 and OSM, investigated at mRNA level

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2018-10-01 | E-MTAB-6080 | biostudies-arrayexpress

Response of several cell lines originated from liver, skin and colon to stimulation by IFNg, hyper-IL6, IL27 and OSM, investigated at microRNA level

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Gene-expression analysis of Oncostatin-M (OSM) signalling in cervical squamous cell carcinomas over-expressing the Oncostatin-M receptor (OSMR)

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