Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse knee joint synovium from different grades of inflammation in mouse collagen induced arthritis (CIA)


ABSTRACT: Knee joint synovium was used for gene expression analysis of mouse collagen induced arthritis (CIA). Synovium was prepared at day 30 after initial sensitization from: healthy controls, CIA animals with no, with mild, with moderate, or with severe joint inflammation. Each sample group is represented by three replicates, each consisting of tissue collected from three to four animals. Experiment Overall Design: The data set consists of 15 samples: five groups with three replicates each. One sample group is from healthy controls, the other groups are from CIA animals with different degress of joint inflammation.

ORGANISM(S): Mus musculus

SUBMITTER: Anton Glück 

PROVIDER: E-GEOD-13071 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis.

Geurts Jeroen J   Joosten Leo A B LA   Takahashi Nozomi N   Arntz Onno J OJ   Glück Anton A   Bennink Miranda B MB   van den Berg Wim B WB   van de Loo Fons A J FA  

Molecular therapy : the journal of the American Society of Gene Therapy 20090818 11


The promoter regions of genes that are differentially regulated in the synovial membrane during the course of rheumatoid arthritis (RA) represent attractive candidates for application in transcriptionally targeted gene therapy. In this study, we applied an unbiased computational approach to define proximal-promoters from a gene expression profiling study of murine experimental arthritis. Synovium expression profiles from progressing stages of collagen-induced arthritis (CIA) were classified into  ...[more]

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