Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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MRNA regulation in normal or TNF-a/IL-4-activated bronchial epithelial cells (BEAS-2B)


ABSTRACT: Illumina microarray experiment on BEAS-2B cells. Cells were seeded 24 h before TNF-a/IL-4 (50 ng/ml) treatment that lasted for 18 h. Cytoplasmic RNA of both normal and activated BEAS-2B cells were collected for microarray. Cells were seeded 24 h before TNF-a/IL-4 (50 ng/ml) treatment that lasted for 18 h. Biological triplicate control and IL4/TNf samples.

ORGANISM(S): Homo sapiens

SUBMITTER: Ann-Bin Shyu 

PROVIDER: E-GEOD-13119 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Coordinated changes in mRNA turnover, translation, and RNA processing bodies in bronchial epithelial cells following inflammatory stimulation.

Zhai Yuxin Y   Zhong Zhenping Z   Chen Chyi-Ying A CY   Xia Zhenfang Z   Song Ling L   Blackburn Michael R MR   Shyu Ann-Bin AB  

Molecular and cellular biology 20081020 24


Bronchial epithelial cells play a pivotal role in airway inflammation, but little is known about posttranscriptional regulation of mediator gene expression during the inflammatory response in these cells. Here, we show that activation of human bronchial epithelial BEAS-2B cells by proinflammatory cytokines interleukin-4 (IL-4) and tumor necrosis factor alpha (TNF-alpha) leads to an increase in the mRNA stability of the key chemokines monocyte chemotactic protein 1 and IL-8, an elevation of the g  ...[more]

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