Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human neuroblastoma samples to identify candidate genes by combining genomic and expression microarrays. Super series see E-GEOD-13136 and E-GEOD-13137


ABSTRACT: This SuperSeries is composed of the following subset Series:; GSE13136: Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: expression data; GSE13137: Identification of candidate neuroblastoma genes by combining genomic and expression microarrays: SNP data Experiment Overall Design: Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Michael Stewart Jackson 

PROVIDER: E-GEOD-13141 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of candidate genes involved in neuroblastoma progression by combining genomic and expression microarrays with survival data.

Łastowska M M   Viprey V V   Santibanez-Koref M M   Wappler I I   Peters H H   Cullinane C C   Roberts P P   Hall A G AG   Tweddle D A DA   Pearson A D J AD   Lewis I I   Burchill S A SA   Jackson M S MS  

Oncogene 20070528 53


Identifying genes, whose expression is consistently altered by chromosomal gains or losses, is an important step in defining genes of biological relevance in a wide variety of tumour types. However, additional criteria are needed to discriminate further among the large number of candidate genes identified. This is particularly true for neuroblastoma, where multiple genomic copy number changes of proven prognostic value exist. We have used Affymetrix microarrays and a combination of fluorescent i  ...[more]

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