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Microarray Innovations in LEukemia (MILE) study: Stage 1 data

ABSTRACT: An International Multi-Center Study to Define the Clinical Utility of Microarray–Based Gene Expression Profiling in the Diagnosis and Sub-classification of Leukemia (MILE Study) Established in 2005, the MILE (Microarray Innovations in LEukemia) study research program included 11 participating centers in three continents. This cohort of n=2,096 samples represents data on the retrospective whole-genome analysis phase. This dataset is part of the MILE Study (Microarray Innovations In LEukemia) program, headed by the European Leukemia Network (ELN) and sponsored by Roche Molecular Systems, Inc. 2096 blood or bone marrow samples of acute and chronic leukemia patients were hybridized to Affymetrix HG-U133 Plus 2.0 GeneChips.

ORGANISM(S): Homo sapiens

SUBMITTER: Wei-Min Liu 

PROVIDER: E-GEOD-13159 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the International Microarray Innovations in Leukemia Study Group.

Haferlach Torsten T   Kohlmann Alexander A   Wieczorek Lothar L   Basso Giuseppe G   Kronnie Geertruy Te GT   Béné Marie-Christine MC   De Vos John J   Hernández Jesus M JM   Hofmann Wolf-Karsten WK   Mills Ken I KI   Gilkes Amanda A   Chiaretti Sabina S   Shurtleff Sheila A SA   Kipps Thomas J TJ   Rassenti Laura Z LZ   Yeoh Allen E AE   Papenhausen Peter R PR   Liu Wei-Min WM   Williams P Mickey PM   Foà Robin R  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100420 15

<h4>Purpose</h4>The Microarray Innovations in Leukemia study assessed the clinical utility of gene expression profiling as a single test to subtype leukemias into conventional categories of myeloid and lymphoid malignancies.<h4>Methods</h4>The investigation was performed in 11 laboratories across three continents and included 3,334 patients. An exploratory retrospective stage I study was designed for biomarker discovery and generated whole-genome expression profiles from 2,143 patients with leuk  ...[more]

PMID: 20406941

Publication: 1/2

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