Transcription profiling of mouse thymus from AKR/J x FVB/NJ F1 versus DBA/2J x FVBF1 reveals 20-fold difference in mammary tumor metastatic capacity, due to differences in inherited polymorphisms.

ABSTRACT: F1 hybrids from (AKR/J x FVB/NJ) and (DBA/2J x FVB/NJ) outcrosses display a 20-fold difference in mammary tumor metastatic capacity, due to differences in inherited polymorphisms. Expression studies were performed to determine whether polymorphism-driven gene expression signatures predictive of outcome could be generated from normal tissues Experiment Overall Design: Thymus from adult F1 animals from (AKR/J x FVB/NJ) and (DBA/2J x FVB/NJ) outcrosses was collected and arrayed on Affymetrics chip to identify basal differences in gene expression between the different genotypes

ORGANISM(S): Mus musculus

SUBMITTER: Kent Hunter 

PROVIDER: E-GEOD-13227 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress