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HNSCC samples vs. normal tonsil samples: self-self hybridization design

ABSTRACT: transcription profiling of human head and neck squamous cell carcinoma (HNSCC) samples vs. normal tonsil samples using a self-self hybridization experimental design on two-color arrays. Used to identify differentially expressed genes in tumor/normal samples, and compare the result to that of the same samples using the reference design experimental setting. Keywords: tumor/normal comparison 8 HNSCC tumor samples and 8 normal tonsil samples. Each was profiled using a self-self hybridization design, where two aliquots of the same sample were labeled with two different dyes (cy3 and cy5) and hybridize to the same array.

ORGANISM(S): Homo sapiens

SUBMITTER: D Hayes

PROVIDER: E-GEOD-13397 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Transcription profiling of human head and neck squamous cell carcinoma (HNSCC) samples vs. normal tonsil samples

Project description:This SuperSeries is composed of the following subset Series: GSE13397: HNSCC samples vs. normal tonsil samples: self-self hybridization design GSE13398: HNSCC samples vs. normal tonsil samples: reference design Refer to individual Series

2009-01-21 | E-GEOD-13399 | biostudies-arrayexpress

HNSCC samples vs. normal tonsil samples: reference design

Project description:transcription profiling of human head and neck squamous cell carcinoma (HNSCC) samples vs. normal tonsil samples using a two-color reference design experimental setting. Used to identify differentially expressed genes in tumor/normal samples, and compare the result to that of the same samples using the self-self hybridization experimental setting. Keywords: tumor/normal comparison 8 HNSCC tumor samples and 8 normal tonsil samples. One sample per array. Two-color reference design with a common reference sample (a modified version of the Stratagene Human Universal Reference) on each array.

2010-05-06 | E-GEOD-13398 | biostudies-arrayexpress

HNSCC samples vs. normal tonsil samples: self-self hybridization design

Project description:transcription profiling of human head and neck squamous cell carcinoma (HNSCC) samples vs. normal tonsil samples using a self-self hybridization experimental design on two-color arrays. Used to identify differentially expressed genes in tumor/normal samples, and compare the result to that of the same samples using the reference design experimental setting. Keywords: tumor/normal comparison

2009-01-22 | GSE13397 | GEO

HNSCC samples vs. normal tonsil samples: reference design

2009-01-22 | GSE13398 | GEO

Homo sapiens

Project description:HNSCC samples vs. normal tonsil samples: self-self hybridization design

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Homo sapiens

Project description:HNSCC samples vs. normal tonsil samples: reference design

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Affymetrix SNP array data for 29 MCL cases

Project description:DNA from four 29 cases, 38 tumor samples (23 PB, 12 LN, 1 Tonsil, 1 colonic biopsy, 1 spleen) and 29 normal DNA from the same patients were analyzed with Affymetrix SNP 6.0 platform for copy number alterations study. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from blood samples, lymph nodes and other tissues like spleen, tonsil and colonic biopsy

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Gene expression profiling of HPV-negative oropharyngeal cancers and Normal benign uvula, tonsil

2014-03-05 | E-GEOD-55547 | biostudies-arrayexpress

Project description:Transcription profiling of human head and neck squamous cell carcinoma (HNSCC) samples vs. normal tonsil samples

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Gene expression profiling of HPV-inactive oropharyngeal cancers and normal benign tissue (uvula, tonsil) from European American patients

Project description:Head and neck cancer (HNC) is the fifth most common malignancy worldwide with an annual mortality rate of 200,000. About 90% of HNC can be classified as head and neck squamous cell carcinomas (HNSCC), of which approximately 75% are attributed to alcohol and tobacco consumption and 25 are associated with human papillomavirus (HPV), predominantly HPV16. HPV-associated OPC have better prognosis and a more favorable response to therapy as compared to HPV-negative tumors. Viral oncoproteins are capable of transforming primary human keratinocytes from either genital or oral epithelia in vitro and most likely play the same role in vivo, by disrupting cell-cycle regulatory pathways leading to a genetic progression to ano-genital cancer and OPC. However, the precise mechanisms by which HPV mediates malignant transformation of keratinocytes in the upper digestive tract epithelia are not entirely clear. HPV E7-mediated inactivation of pRb results in overexpression of p16INK4A, which is commonly used as a clinical surrogate marker for HPV positivity/activity. However, high p16INK4A alone has insufficient sensitivity and specificity as a biomarker of HPV positivity in different mucosal sub-sites of HNC. Therefore, increasing emphasis is being placed on the assessment of viral load and E7 oncogene expression, resulting in further classification of HPV positive OPC as HPV-active and HPV-inactive. This study aimed to compare the gene expression profiles of HPV-inactive oropharyngeal squamous cell carcinoma (OPC) and normal benign uvula/tonsil tissues from European American patients and determine what biological processes and pathways are affected in HPV-inactive OPCs in this ethnic group. ANALYSIS 7: Two-condition, one-color experiment: European American (EA) HPV-inactive oropharyngeal tumor samples and normal benign uvula/tonsil tissues. Biological replicates: 4 EA HPV inactive samples and 4 EA Normal samples.

2014-03-05 | E-GEOD-55548 | biostudies-arrayexpress

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